Hormonal therapy or management of cancer
it has been found that up to 15%of tumors may have responsive elements
Some tumors, most notably breast and prostate cancers. originate from tissues whose growth is under hormonal control. The first attempts at hormonal therapy were through surgical ablation of the organ producing the hormones of interest, such as oophorectomy for breast cancer. Currently, hormonal manipulation is accomplished by several different modes .
Hormones or hormone like agents can be administered to inhibit tumor growth by blocking or antagonizing the naturally occurring substance, such as estrogen antagonist tamoxifen. Other substances that block the synthesis of the natural hormone can be administered as alternatives. Aromatase inhibitors, for example, block the peripheral conversion of endogenous androgens to estrogens in postmenopausal women.
Hormonal therapy provides a highly tumor-specific form of therapy in sensitive tissues. In breast cancer, estrogen and progesterone receptor status is used to predict the success of hormonal therapy. Recently, several other biologic variables have been found to have an impact on the success of hormonal therapy, and these variables are likely to be incorporated into clinical practice in the near future.
Hormonal Anticancer Agents like as
testosterone and fluoxymesterone in breast cancer
aromatase inhibitors prevent oestrogen production from peripheral fat no effect on ovarian oestrogen so post menopausal only recent evidence of superior survival in advanced disease compared with tamoxifen for 3rd generation aromatase inhibitors eg anastrazole